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Neue Publikation: Weighted Consensus Segmentations

Präsentation in der RCB Contemporary Webinar Series

Am Freitag den 11.12 gab Prof. Dr. Oliver Ebenhöh eine Präsentation in der RCB Contemporary Webinar Series organisiert von Regional Centre of Biotechnology in Indien. Wenn Sie daran interessiert sind die aufgezeichnete Präsentation anzusehen, kontaktieren Sie uns.

Neue Publikation: 'From Sequence to Information'

Unser neues Review 'From Sequence to Information' ist veröffentlicht und verfügbar (natürlich Open Access) unter  https://royalsocietypublishing.org/doi/10.1098/rstb.2019.0448.

Neue Publikation

Dr. Adélaïde Raguin hat ein neues Paper veröffentlicht: Raguin, A., Kern, N., & Parmeggiani, A. (2020). Stochastic modelling of collective motor protein transport through a crossing of microtubules. Journal of theoretical biology, 505, 110370.

https://doi.org/10.1016/j.jtbi.2020.110370 . (Also available via arxiv.org/abs/2006.10416)

Neuer Seitenabschnitt: Modelle

Wir haben einen neuen Abschnitt auf unserer Internetseite, "Modelle", hinzugefügt. In diesem Abschnitt finden Sie Links und Beschreibungen einiger der Modelle, die in unserem Institut zur Analyse komplexer biologischer Phänomene verwendet werden

Covid-19 und Pflanzen aus einer rechnerischen Perspektive

Was haben epidemiologische Modelle, die die Ausbreitung des Coronavirus simulieren, mit der Vorhersage der Photosyntheseleistung von Pflanzen gemeinsam? Speziell für die in diesem Monat erscheinende Ausgabe von Planter's Punch von CEPLAS hat unser Team ein Video erstellt, in dem wir Zusammenhänge zwischen der Modellierung von Infektionskrankheiten und Pflanzen erklären. Werfen Sie einen Blick darauf.

Unsere Forscher arbeiten am ersten Video über unsere Arbeit im Institut

Schauen Sie sich den kleinen Vorgeschmack auf unseren neuen YouTube-Kanal an: https://youtu.be/1eHTAlvTGsw

Theorie-Seminar: Lars Folke Olsen (Universität von Süddenmar)

Diesmal präsentiert Lars Folke Olsen ("Kopplung der Dynamik des Stoffwechsels an den Zustand des intrazellulären Wassers") in unserem Theorieseminar. Er führt uns in die Assoziationsinduktions-Hypothese (AI) ein, eine fluoreszierende Methode zur Untersuchung der Polarisation von Wasser in Zellen und ihre Anwendung bei der Erforschung der Oszillation von Glykolyse-Zwischenprodukten, sowohl von ATP als auch von NADH in Hefe.

Meeting der QTB-Gruppe in der Zeit der Pandemie

Unsere Gruppe trifft sich regelmäßig, um sich gegenseitig über den Fortschritt der Forschung auf dem Laufenden zu halten. Wir teilen nicht nur unsere Ergebnisse, sondern auch Bedenken hinsichtlich der aktuellen globalen Situation, der Zukunft akademischer Konferenzen und des Bedarfs an weiteren Seminaren, die aus unserem Institut kommen. Heute vor dem Treffen ist es uns trotz des derzeit obligatorischen Kontaktverbotes gelungen, unsere Tradition durch ein Online-Frühstück am Leben zu erhalten. Wir alle hoffen, dass das nächste geplante Frühstück im Mai bereits an der Universität organisiert werden kann.

Theory Seminar: Christopher Marx

Christopher Marx will give a talk in our theory seminar. The title of his presentation is "A purely Lamarckian ‘evolution’ permits survival of a bacterium
to a lethal stressor." We are looking forward to learn more about his fascinating research.

Theory Seminar: Elad Noor

This time Elad Noor from ETH Zurich will present his talk "How thermodynamics shapes the design of carbon fixation cycles" in the theory seminar. We are happy to have him here and looking forward to a lot of interesting discussions as well as learning more about his fascinating research.

New Publication: Saadat, Nies, Rousset, Ebenhöh

Our new review on "Thermodynamic limits and optimality of microbial growth" is now published! You can find it here

Mathematical modelling during the CEPLAS Friday

Dr. Anna Matuszyńska and Dr. Adélaïde Raguin will give talks after this year's CEPLAS General Assembly. Dr. Matuszyńska will talk about her recently launched DFG project on secondary metabolism of the glandular trichomes, whilst Dr. Raguin will give an overview of several project where she has used stochastic modelling to address biological questions, with the focus on modelling plant cell wall degradation. Talks are open to the public.

  • Dr. Anna Matuszyńska, Quantitative and Theoretical Biology, HHU
    • Title: "Cell Factories: the origin of high metabolic fluxes in glandular trichomes"
  • Dr. Adélaïde Raguin, Quantitative and Theoretical Biology, HHU
    • Title: "Plant cell wall degradation: a numerical modelling approach"

Location: HHU, Building 26.11, Lecture Hall 6E, The talks start at about 3pm.

New Publication: Dr Adélaïde Raguin

Mutation in the enzyme tRNA synthetase (aaRS) can lead to severe diseases including neurological disorders. In a new article our postdoc Dr. Adélaïde Raguin investigates with collaborators from University of Aberdeen the aetiology of such diseases by using sophisticated stochastic models combined with experimental data. See the article here!

Congratulations to Dr. Francesco Tacchino

We congratulate Dr. Francesco Tacchino, our former master student, for the successful defense of his PhD thesis at the university of Pavia.

New publication: Dr. Adélaïde Raguin & Prof. Dr. Oliver Ebenhöh

Starch his one of the most important plant-derived carbohydrates for human society. We use it as raw material in several industries and it is crucial for our daily diet. But have you ever wondered how this glucose polymer is synthesized in plants? Research is far from having a full understanding of this process. In a new review Dr. Adélaïde Raguin and Prof. Dr. Ebenhöh worked together with scientists from the ETH Zurich (Switzerland) and the John Innes Centre (UK) to explore as well as reflect possible theoretical and experimental approaches to broaden our knowledge about the synthesis of starch.

Check it out here

We welcome our new postdoc Dr. Rachel Denley-Bowers!

We welcome our new postdoc Dr. Rachel Denley-Bowers. As a scientist and member of the Cluster of Excellence in Plant Sciences (CEPLAS) with theoretical and experimental expertise she will work on diverse interesting topics in the field of plant related biology. We are happy to have her in our group and looking forward to many interesting discussions.

After completing her PhD about "the economic of stomatal development" at the University of Sheffield (PIs: Stuart Casson and Nick Monk), Dr. Rachel Denley-Bowers did her first postdoc position at the John Innes Center (one of the biggest plant science centers in the UK), where she was involved in elucidating the properties of starch and its food biotechnological apllications.

A nice end of the year: Two new preprints from our institute

Whether it is information encoded in the sequences of life or the question if microbes are thermodynamically optimised machines, we are interested in numerous biological topics. In two new reviews (preprints) several members of our group discuss interesting ideas and facts about fundamental principles behind biological systems. A nice end of the year!

Theory Seminar: Rachel Denley Bowers (13.12.19)

This Thursday our future postdoc Rachel Denley Bowers (currently at the John Innes Centre Norwich) is going to present her work on stomatal placements and potential cost in the model plant Arabidopsis thaliana. The title of her talk is: "Modelling plant metabolism and development". We are really looking forward to hear about her past research and are happy to welcome Rachel in our team.

Place and time as usual.

Theroy seminar: Rahmi Lale (19.12.19)

On Thursday the 19th of December Rhami Lale from the Norwegian University of Science and Technology is going to present the talk "Towards Rational Design of Promoters"  during the Theory seminar.

New Publications!!!

From quantum mechanics to hidden patterns of natural variation in plants; the institute of Quantitatve and Theoretical Biology was involved in two new exiciting studies:

  1. Our paper on quantum mechanical models of the Q-cycle in the cytochrome b6f complex is now online: www.nature.com/articles/s41598-019-52842-x
  2. Our preprint on natural variations in the accumulation of aliphatic glucosinolates in Arabidopsis thaliana is now available on bioRXiv: https://www.biorxiv.org/content/10.1101/838227v1

Both papers were written in collaboration with former memebers of the QTB group. Dr. Antonella Succuro (currently University Bonn, Germany) a former particle physicist now concentrating on the complex laws of life and Dr. Suraj Sharma, a talented former PhD student now postdoc at the University of Tromsø.

QTB Annual Symposium

This last weekend we had our annual QTB symposium. It was a great time with a lot of scientific discussions, presentations and a ton of new ideas for current and future projects. We talked about possible workshops of time series analysis, how to combine modelling approaches of polymer biochemistry and genome-scale models, the ethical responsibilities of scientists to present their research to the public, and ideas for possible master or bachelor projects (If you are interested, write us an e-mail). This year we stayed at the Forsthaus Lahnquelle in Netphen, a hotel in the middle of nowhere with really delicious food and a cosy atmosphere.

Theory Seminar: Janani Ravichandran, Friday (20.09.2019)

This friday at 2pm we are going to have a theory seminar. Janani Ravichandran will talk about her work at the Institute of Mathematical Sciences, Chennai, India. Location: Room

Have a look at our research section :)

We updated our undefinedresearch area. Have a look and find out what our research is about. Each section includes a short description of the project and suggests scientific articles that could help you to learn more about the topic. If you are interest in one of our projects, please contact the person who is responsible (you will find contact information by clicking on the names ). We are eager to discuss our work an broaden our scientific network. Also students are welcome. If you want to know how we conduct our research, do not hesitate to ask and write us an e-mail.

New PhD student: Chilperic Armel Foko Kuate

We welcome our new PhD student Chilperic Armel Foko Kuate. As part of the PoLiMeR Marie Skłodowska-Curie Innovative Training Network he will investigate the role of lipids in humans by creating and validating sophisticated mathematical models of lipid synthesis and storage in the liver.

Nima Saadat held his first talk at an international conference

Our PhD student Nima Saadat held his first talk at an international conference (Metabolic Pathway Analysis (MPA) in Riga, Latvia), presenting work he and Dr. Ovidiu Popa conducted to elucidate the role of prophages in metabolic networks . The title of his presentation was "Impact of prophage encoded enzymes on the metabolic capacity of the hosts". He did a great job and we are all proud of him.

Do you know....

...that the institute of Quantitative and Theoretical Biology is very interdisciplinary. Our members have a diverse background and combine different field of science to do great research. This results in many interesting project ranging from plant biology (polymer biochemistry, photosynthesis, resource allocation, photoacclimation) over phage genomics and metabolic network reconstruction / modelling (scopes and reconstruction of non-model organism genome scale models) to  investigations about mental diseases (collaboration with the undefinedKorthlab) and spinal cord injuries (PSINK undefinedsee). Soon our research section will be updated and you can read all about it in more detail :)

Have a nice week and when you have any questions do not hesitate to ask!

Theory Seminar 18.07.2019: Pia Rose

After a long time we are going to have a theory seminar again. Pia Rose from the Humboldt University Berlin will introduce us to "mathematical models of heart-arrythmias".

It is a very interesting topic, so do not miss it! :)

Place and time as usual (, this thursday 18.07.2019 at 11am)

Journal Club: Sascha Ollertz

In this Journal Club Sasscha Ollertz, a bachelor student in our group working on modelling amino acid synthesis, is the chair of our weekly journal club. He is going to present us a paper about viruses that could be used for producing electrical energy. You can find the paper undefinedhere (not open access). The plan for upcoming papers in the journal club can be foundundefined here.

Journal Club: Meik Thiele

Due to a lack of time and holidays we had no journal club these last two weeks, but now it's back and Meik Thiele, a bachelor student working on metabolic scopes in genome scale models of cyanobacteria, was the first of the bachelor students who volunteered to present a paper :) He will tell us something about the "energetic cost of building a virus" (paper by Gita Mahmoudabadi, Ron Milo, and Rob Phillips. You can find the paper undefinedhere).

PS: We now have a wiki site where you can find the planned journal club topics. If you are interested, check it out undefinedhere.

First-time proposal by Dr. Matuszyńska has been funded

We have a great pleasure to inform that Dr. Matuszyńska has been granted three years funding by the Deutsche Forschungsgemeinschaft, to conduct an interdisciplinary project in a collaboration with Prof. Dr. Alain Tissier (IPB Halle). "iPHACTORY: Interdisziplinäre Untersuchung  von photosynthetischen glanduläre Trichome als zelluläre Stoffwechselfabriken" proposes a combined multi-omics and modelling approach towards understanding trichome metabolism in tomato. Congratulations to Dr. Matuszyńska. We are looking forward to the first results.

More about the project soon.

Fascination of Plants Day 2019

As several times before the Institute of Quantitative and Theoretical Biology together with the Cluster of Excellence on Plant Sciences (undefinedCeplas) organized the Fascination of Plants Day here at the Heinrich-Heine-University Duesseldorf. We invited students from different elementary schools (Duesseldorf and surrounding) to visit the HHU and learn about plants in several small experimental settings. Do plants breathe? Do they move? Why are they green? Can they shine or swim? All these questions are covered and will be explained.

We hope that this day will be great and that the students have as much fun as we have.

Open Postdoc Positions at the Institute of Qunatitative and Theoretical Biology

We have currently some postdoctoral positions free for applications. If you are interested check out our undefined"Offene Stellen/ Open Positions" page

Journal Club: Marvin van Aalst (16.5.2019)

Now its Marvin's turn to present us an exciting paper in the journal club. The title of the paper he presents is: "A temporal shift in resource allocation facilitates flowering before leaf out and spring vessel maturation in precocious species" (by  Jessica A. Savage). You can find the paper undefinedhere

Echt oder Fake Tuesday 14.5.2019 Lecture Hall 5K

Tomorrow a few of our members will be part of "ECHT oder FAKE". It is an event where scientists from different disciplines present their topics in an easy to understand style but not everything they say is true. Therefore, it is the audience's task to figure out what is correct or not.

We are very excited and looking forward to an evening full of fun, interesting talks and science.

Oh.. and the person who can best figure out what is true or fake can win a prize ... fingers crossed :)

Theory Seminar: Wolfram Liebermeister ( Wednesday 08.05.2019, 11am)

Wolfram Liebermeister from the INRA Jouy-en-Josas will give a very interesting theory seminar with the title "Resource allocation in kinetic models of cell metabolism"

Guest: Wolfram Liebermeister

This week we have a guest at our Institute. undefinedWolfram Liebermeister is a well known systems biologist, who focuses on control and optimal metabolic states in cells.

Journal Club: Prof. Dr. Oliver Ebenhöh

This time (Thursday 25-4-2019) our PI Prof. Dr. Oliver Ebenhöh is the chair of our Journal Club. He is going to present us a paper published by Yinan M. Bar-On, Rob Phillips and Ron Milo that attempts to give a census of the biomass on earth. You can find this very interesting paper undefinedhere.

Counting cells

Want to know how to make cells count? Read the our recent paper led by
our collaborator Sean Colloms (undefinedlink) from Glasgow University. Find the paper undefinedhere

Journal Club: Dr. Ovidiu Popa

This Thursday Dr. Ovidiu Popa, a postdoc in our institute working on phage genetic elements in prokaryotic cells and the diversification in Arabidopsis thaliana populations, is going to present us a paper about the systematic discovery of antiphage defense systems in microbial pangenomes (undefinedhere).

New PhD student Yvan Rousset

We welcome our new PhD student Yvan Rousset. He is part of the undefinedPoLiMeR network and is going to work on  mathematical models of human diseases.

Theory Seminar: Valerii Sukhorukov

This Thursday in our Theory Seminar Valerii Sukhorukov is going to talk about a spatially resolved model of mitochondrial network and physiology.

And again Journal Club: Felix Risse 28.3.2019

This time Felix Risse, a master student focusing on the mathematical modelling of auxin pattern formation in plants, presents us a whole cell model originally proposed by Karr et al.. Please find the paper undefinedhere.

New Paper: Balancing energy supply during photosynthesis – a theoretical perspective

GREAT NEWS! :The paper "Balancing energy supply during photosynthesis - a theoretical perspective" written by our postdoc Dr. Anna Matuszyńska, our phD student Nima Saadat and our head of institute Prof. Dr. Oliver Ebenhöh is now available. You can find the paper in the Journal Physiologia Plantarum - it is open access (Clickundefined here)

Journal Club: Nima Saadat

This Thursday Nima Saadat, a phD student in the institute working on genome scale models and the plastic consuming bacterial species Idonella sakaiensis , is going to present us a paper about diet induced changes of our gut microbiome. You can find the paper undefinedhere.

Journal Club: Dr. Adélaïde Raguin

This Thursday Dr. Adélaïde Raguin, a postdoc in our institute working on stochastic models of starch and lignin formation and degradation, is going to present us a paper dealing with a quantitative description of actin networks and how these influence the lamellipodium motility in cells.  You can find the paper undefinedhere

A new paper from our institute is going to be published

GREAT NEWS! :The paper "Balancing energy supply during photosynthesis - a theoretical perspective" written by our postdoc Dr. Anna Matuszyńska, our phD student Nima Saadat and our head of institute Prof. Dr. Oliver Ebenhöh is going to be published in the Journal Physiologia Plantarum. The link will follow as soon as it is accessible.

Journal Club 7.3.2019

We will have our next Journal Club this Thursday (7.3.2019). Tim Nies a master student from our institute is going to talk about microbial communities and an extended MacArthur-Consumer-Resource-Model proposed by Marsland III et al.

You can find the paperundefined here

First Journal Club

We will have our first Journal Club !!! Thomas Wenske, a master student in our institute working on phage genomics, is going to talk about the paper "Phage Therapy: Going Temperate?" by Rodrigo Monteiro et al., Cell 2018. You can find the paper undefinedhere

Theory Seminar: Jürgen Schönborn

Jürgen Schönborn (Institute of Systems Biology of Lipid Metabolism at the Heinrich-Heine-University) will talk about Flux Balance Modelling in Drosophila larvae

A new paper on modelling microbial populations is published

Our paper on modelling emergent subpopulations of E.coli has been
published. Click undefinedhere

Balancing energy supply during photosynthesis - a theoretical perspective

Our theoretical view of photosynthesis as a molecular economy supply-demand system has just been published on the BioRxiv. Hope to read it soon in the Special Issue on Photosynthesis of the Physiologia Plantarum.

First software paper on-line

We have released the first QTB software. The modelbase package is a free expandable Python package for building and analysing dynamic mathematical models of biological systems. Originally it was designed for the simulation of metabolic systems, but it can be used for virtually any deterministic chemical processes. We are proud that it is the first paper with two of our bachelor students as co-authors. undefinedOpen access

Another Poster Prize goes to our Institute

Dr. Anna Matuszyńska has received the People's Choice Award for her poster presented during the second edition of the Science Polish Perspective Meetup in Berlin. Anna presented her work on the MeProPhot project, supported by the funds from the Strategischer Forschungsfonds (SFF).

Best Poster Prize for our PhD student

Our PhD student Nima Saadat has won the prize for the Best Poster Presentation during this year's International Study Group for Systems Biology (ISGSB) conference in Tromsø, Norway. Congratulations and many more successes on your way!

Strategischer Forschungsfonds for Dr. Matuszyńska

Dr. Matuszyńska has been granted 10.000 € from the Strategic Research Fund, to start her own project MeProPhot: Data mining to investigate high Metabolic Productivity of Photosynthetic glandular trichomes. The project will be running from the 1st of July till the end of the 2018. Two Student Assistants (Wissenschaftliche Hilfskraft) will be employed to support this project, so if you are interested in trichome biology please monitor our News section for more details.

BIO.NRW.academy. QTB meets Industry

Dr. Matuszyńska will give a talk during theundefined BIO.NRW.academy, a full-day symposium on Tuesday, May 15 at Forschungszentrum Jülich. For the first time the BIO.NRW.academy invites together leading industry representatives and young scientists to present concrete questions of the industry and to get to know the current research at the junior level in the same field. It is an experiment from which the organisers expect a new dynamic in technology transfer in the life sciences in North Rhine-Westphalia and we are happy to be a part of it.

Our paper on modeling heat shock response in Chlamy is out

The work conducted by our alumni Dr. Magni and Dr. Succurro during their position at the Institute has been published today in the Journal of The Royal Society Interface. They studied the dynamics of heat shock response (HSR) in the photosynthetic model organism Chlamydomonas reinhardtii with a data-driven mathematical model of HSR. With their model, they demonstrate that the HSR of C. reinhardtii efficiently avoids the accumulation of misfolded proteins under conditions most likely to prevail in nature.

You can download the paper from the undefinedjournal site.

On-line guest lecture at Ferdowsi University of Mashhad

Dr. Matuszyńska has been invited to give two lectures for systems biology PhD students at the F.U.M Agriculture Faculty Ferdowsi University of Mashhad. The first lecture will take place on the 1st of May and will focus on application of mathematical models in photosynthetic research. It is our first, of hopefully many, on-line lecturing experiences.

Our work on modelling phosphorus uptake in microalgae is published

Our paper on modelling phosphorus (P) uptake is finally out! The study of molecular mechanisms underlying P uptake and storage in microalgae has become recently of great interest. There is a critical need to practise P recovery from waste and establish a circular economy applicable to P resources. In our paper, we review phosphate models, which express the growth rate as a function of intra- and extracellular phosphorus content for better understanding of phosphate uptake and dynamics of phosphate pools.

The research was performed in a collaboration with Dr. Nedbal from the Forschungszentrum Jülich.

Date for MPA 2019 confirmed

The next MPA (Metabolic Pathway Analysis) meeting moves from Bozeman (USA) to Latvia! It will take place in Riga,  between 12 - 16 Aug 2019, organised by Egils Stalidzans of the University of Latvia. The MPA conference series is one of the preeminent international meetings for the scientific community analysing the topological structure-function relationships of metabolic networks. The QTB Team regularly takes an active part in the meetings and you will definitely see some of us in Riga next year.

Dr. Popa discusses evolution in Venice

Dr. Ovidiu Popa is giving this week a talk at the Stochastic Models in Ecology and Evolutionary Biology (undefinedSMEEB 2018) workshop in Venice. His presentation entitled "Evolutionary Footprint in the Genome of Arabidopsis thaliana" will cover his newest results on the Arabidopsis project.

Tutorial lectures during the aSSB 2018

Next week, from 19th to 23rd of March 2018, Prof. Ebenhöh and Dr. Popa will give a tutorial lectures on basic concepts of mathematical modelling with Python, as a part of the programme of the aDvances in Systems and Synthetic Biology (aSSB) thematic research school. The school started in 2002 and it is the 16th edition, taking place in Évry. To read more about the school visit: undefinedhttps://assb.lri.fr/en/index.php

Full Professorship

Today, our Head of the Institute, Dr. Oliver Ebenhöh was appointed Professorship at the Faculty of Mathematics and Natural Sciences. The QTB Team celebrated together this well deserved achievement and wish great success with the new position.